Cellular mechanisms of neurodegenerative diseases and conditions
Neurodegenerative disease is a common term for a range of cellular pathophysiological processes which primarily affect the neurons in the brain and the spinal cord resulting in their injury and death.
Neurobiophysics of dynamic interactions between neurons and glia
Multiple spatial and temporal scales of neurons-glia interactions are closely intertwined and they lie at the core of the macroscopic pathologies studied.
Biomarkers in neurodegenerative processes
The main goal is finding a reliable in vivo biomarker for diagnosis, prognosis and follow-up of the therapeutic response in neurodegeneration.
The role of extracellular matrix in structural plasticity
Our main protein of interest, Tenascin C is a large extracellular matrix glycoprotein up-regulated during embryogenesis, in wound healing, and in tumor tissues, while its cleavage is performed by matrix metalloproteinases thus promoting neuronal structural and functional plasticity.